JH295
CAS No. : 1311143-71-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $450 | In-stock |
| 10mg | $800 | In-stock |
| 25mg | $1550 | In-stock |
| 50mg | $2350 | In-stock |
| 100mg | $3400 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-116423 |
| M.Wt: | 320.35 |
| Formula: | C18H16N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 55 mg/mL (ultrasonic) |
JH295 is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint[1]. JH295 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IC50 & Target: IC50: 770 nM (Nek2)[1] In Vitro: JH295 (Compound 16; 0.08-20 μM; 45 minutes; RPMI7951 cells) treatment inhibits WT Nek2 in cells with an IC50 of ~1.3 μM, whereas it has little effect on the C22V mutant[1].
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