PFM39
CAS No. : 1310744-67-2
| Size | Price | Stock |
|---|---|---|
| 10mg | $230 | In-stock |
| 25mg | $460 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1180 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120951 |
| M.Wt: | 219.26 |
| Formula: | C10H9N3OS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity[1].
In Vitro: PFM39 (100 μM) treatment impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR)[1].
PFM39 (50 μM) inhibits homologous recombination (HR) without significantly increasing NHEJ[1].
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