VBY-825
CAS No. : 1310340-58-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $340 | In-stock |
| 5mg | $850 | In-stock |
| 10mg | $1450 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-15958 |
| M.Wt: | 535.55 |
| Formula: | C23H29F4N3O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
VBY-825 is an orally available novel reversible cathepsin inhibitor that has high inhibitory potency against cathepsin B, L, S and V, and possesses anti-tumor, anti-inflammatory and analgesic effects[1][2][3].
In Vitro:VBY-825 (0-300 nM) inhibits both heavy chain isoforms of cathepsin L and cathepsin B with IC50 values of 0.5, 3.3 and 4.3 nM in HUVEC cells[1].
In Vivo:VBY-825 (10 mg/kg, via gavage, once daily, 14 days) reduces pain behaviors in a mouse bone cancer model[2].
VBY-825 inhibits inflammation in mouse models of gout, peritonitis, and arthritis[3].
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