Oxybenzone
CAS No. : 131-57-7
(Synonyms: Benzophenone 3)
| Size | Price | Stock |
|---|---|---|
| 25g | $17 | In-stock |
| 100g | $27 | In-stock |
| 500g | $33 | In-stock |
| 1000g | $64 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-A0067 |
| M.Wt: | 228.25 |
| Formula: | C14H12O3 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 100 mg/mL (ultrasonic) |
Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells[1][2][3].
In Vitro: Oxybenzone (Benzophenone 3) (25 μM; 24 hours) decreases the relative RXRβ and RXRγ protein levels by 61 and 56%, respectively and increases the relative RXRα protein level by 49%[3].
Oxybenzone (25-100 μM; 24 hours) induces an increase in caspase-3 levels in primary cultures of mouse neocortical cells at 7 DIV. Oxybenzone-induced apoptosis involves the activation of RXRα signaling and the impairment of RXRβ/RXRγ signaling. Oxybenzone (25 μM; 24 hours) inhibits global DNA methylation as well as reduced HDAC and HAT activities in mouse embryonic neuronal cells[3].
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