Dioxybenzone

Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study^[1][2][3]. In Vitro:Dioxybenzone (0.1-1 μM, 24-72 h) exhibits estrogenic disrupting effect via increasing the mRNA expressions and production of the growth factors responsible for epithelial proliferation, including Fgfs and Igf-1 in human endometrial stromal cells (HESCs)^[2].
Dioxybenzone (0.1-1 μM, 24-72 h) up-regulates the mRNA expressions of inflammatory cytokines especially IL-1β in HESCs^[2].
Dioxybenzone (20-600 μM, 24 h) chlorination decreases its UV absorbance and generates cytotoxic product(s) in human diploid fibroblasts (HDFs) ^[3].
In Vivo:Dioxybenzone (0.0025% in drinking water; one week prior to tumor initiation and lasts 2 weeks) exhibits a significant chemopreventive activity against mouse skin carcinogenesis in NOR-1-induced mice model^[1].
Dioxybenzone (20-100 mg/kg; i.p.; daily for 3 days) increases mRNA expressions of estrogen signaling and inflammation target genes in mice uterus^[2].
Dioxybenzone (20-100 mg/kg; i.p.; daily for 3 days) significantly induces transcriptome aberration involved in cancer, reproductive system disease and inflammatory disease^[2].