m-PEG5-MS
CAS No. : 130955-38-3
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| Cat. No. : | HY-116186 |
| M.Wt: | 330.40 |
| Formula: | C12H26O8S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
m-PEG5-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG5-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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