L-2-Hydroxyglutaric acid
CAS No. : 13095-48-2
(Synonyms: (S)-2-Hydroxyglutaric acid)
| Size | Price | Stock |
|---|---|---|
| 67.52 mM * 1 mL in Ethanol | $319 | In-stock |
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| Cat. No. : | HY-113039 |
| M.Wt: | 148.11 |
| Formula: | C5H8O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2]. In Vitro: L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].
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