SKI2496
CAS No. : 1308378-95-1
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| Cat. No. : | HY-117982 |
| M.Wt: | 739.68 |
| Formula: | C35H36F7N5O5 |
| Purity: | >98 % |
| Solubility: |
SKI2496 is an orally active GnRH receptor antagonist (IC50: 0.25 nM for hGnRHR, 13.2 nM for monkey GnRHR, 279.2 nM for rat GnRHR). SKI2496 blocks Ca2+ flux with an IC50 value of 0.76 nM. SKI2496 inhibits ERK1/2 phosphorylation with an IC50 value of 2.6 nM. SKI2496 inhbits serum LH concentrations, and can be used for research of sex hormone-dependent disorders[1].
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