Lecimibide
CAS No. : 130804-35-2
(Synonyms: DuP 128)
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| Cat. No. : | HY-16281 |
| M.Wt: | 590.77 |
| Formula: | C34H40F2N4OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research[1][2].
In Vitro:Lecimibide (DuP 128)(10 μM, 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells[1].
In Vivo:Lecimibide (DuP 128) (i.v., 2.2 mg/kg/day) significantly reduces total plasma triglyceride and very low-density lipoprotein (VLDL) triglyceride concentrations in pigs fed high fat and cholesterol levels, respectively 36% and 31%. There are no significant effects on total cholesterol, VLDL cholesterol, LDL cholesterol, HDL cholesterol, or LDL apoB concentrations[2].
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