Neticonazole
CAS No. : 130726-68-0
| Size | Price | Stock |
|---|---|---|
| 25mg | $83 | In-stock |
| 50mg | $149 | In-stock |
| 100mg | $242 | In-stock |
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| Cat. No. : | HY-106541 |
| M.Wt: | 302.43 |
| Formula: | C17H22N2OS |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic);1M HCl : 100 mg/mL (ultrasonic;adjust pH to 1 with HCl) |
Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects[1][2][3].
IC50 & Target: Fungal [1]
In Vitro: Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels[2].
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells[2].
Neticonazole is also an orally active exosome biogenesis and secretion inhibitor[3].
In Vivo: Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells[3].
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