LY2940094
CAS No. : 1307245-86-8
(Synonyms: BTRX-246040)
| Size | Price | Stock |
|---|---|---|
| 5mg | $220 | In-stock |
| 10mg | $385 | In-stock |
| 25mg | $770 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-114452 |
| M.Wt: | 480.96 |
| Formula: | C22H23ClF2N4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 41.67 mg/mL (ultrasonic) |
LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models[1].
IC50 & Target: Ki: 0.105 nM (NOP receptor)[1]
Kb: 0.166 nM (NOP receptor)[1]
In Vivo: LY2940094 (3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity[1].
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