Dorzolamide (hydrochloride)
CAS No. : 130693-82-2
(Synonyms: L671152 hydrochloride; MK507 hydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $43 | In-stock |
| 10mg | $53 | In-stock |
| 25mg | $71 | In-stock |
| 100mg | $86 | In-stock |
| 250mg | $190 | In-stock |
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| Cat. No. : | HY-B0109A |
| M.Wt: | 360.90 |
| Formula: | C10H17ClN2O4S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 12.5 mg/mL (ultrasonic) |
Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1].
In Vitro: Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM)[2].
In Vivo: Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively)[3].
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