Bindarit
CAS No. : 130641-38-2
(Synonyms: AF2838)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $145 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $425 | In-stock |
| 100mg | $720 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-B0498 |
| M.Wt: | 324.37 |
| Formula: | C19H20N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 46 mg/mL |
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity[1]. IC50 & Target: MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8[1] In Vitro: Bindarit (10-300 μM; 48 hours) at 100 µM and 300 µM significantly inhibits platelet derived growth factor-BB (PDGF-BB)-induced rat VSMCs proliferation by 27% and 42%, respectively[1]. In Vivo: Bindarit (50 mg/kg; oral administration; every day; for 4 months, 6 months, 8 months; NZB/W F1 female mice) delays the onset of proteinuria and significantly protects from renal function impairment. Bindarit completely prevents monocyte chemoattractant protein (MCP-1) up-regulation[2].
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