Yangambin
CAS No. : 13060-14-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $152 | In-stock |
| 5mg | $380 | In-stock |
| 10mg | $600 | In-stock |
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| Cat. No. : | HY-N4267 |
| M.Wt: | 446.49 |
| Formula: | C24H30O8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2]. IC50 & Target: PAF, Ca2+ channels[1]
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