Vatinoxan (hydrochloride)
CAS No. : 130466-38-5
(Synonyms: MK-467 (hydrochloride); L-659066 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $850 | In-stock |
| 10mg | $1450 | In-stock |
| 25mg | $2610 | In-stock |
| 50mg | $4150 | In-stock |
| 100mg | $6200 | In-stock |
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| Cat. No. : | HY-19057A |
| M.Wt: | 454.97 |
| Formula: | C20H27ClN4O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
Vatinoxan hydrochloride (MK-467 hydrochloride;L-659066 hydrochloride) is a peripheral α2 adrenergic receptor antagonist. IC50 & Target:α2 adrenergic receptor[1] In Vivo: Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects. Vatinoxan attenuates or prevents dexmedetomidine’s systemic hemodynamic effects in a dose-dependent manner when given simultaneously i.v. but has no effect on the pulmonary outcome in conscious dogs. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function[1]. Vatinoxan dose-dependently attenuates the bradycardia associated with dexmedetomidine, and shortens the sedative effect without altering its quality. Vatinoxan may be useful in attenuating reductions in heart rate in conscious catsadministered dexmedetomidine[2].
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