A71623
CAS No. : 130408-77-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $295 | In-stock |
| 5mg | $885 | In-stock |
| 10mg | $1400 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-P1096 |
| M.Wt: | 840.96 |
| Formula: | C44H56N8O9 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
A71623, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC50s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively[1].
IC50 & Target:IC50: 3.7 nM (CCKA receptor in radioligand binding assays)[1]
In Vitro: In guinea pig gastric glands, the affinities of A-71623 for the cholecystokinin (CCK)-B/gastrin receptor were 11 μM[1].
In Vivo: A71623 (A-63387; i.c.v., but not i.p., injections) reduces food intakes and suppresses intakes of a liquid diet in both deprived and sated rats[2].
A71623 dampens Purkinje neuron pathology and associates deficits in motor performance in Pcp2-ATXN1[30Q]D776;Cck-/- and Pcp2-AXTN1[82Q] mice[3].
A71623 improves motor performance of Pcp2-ATXN2[127Q] SCA2 mice[3].
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