MCPG (sodium)
CAS No. : 1303994-09-3
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| Cat. No. : | HY-103570 |
| M.Wt: | 231.18 |
| Formula: | C10H10NNaO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) [1].
In Vitro:MCPG (300 μM, 1, and 3 mM) inhibits the concentration-dependent increase of phosphoinositol (PPI) hydrolysis induced by 1S, 3R-aminocyclopentane-1, 3-dicarboxic acid (ACPD) in hippocampus sections [1].
MCPG (20 mM, 200 mM) has a selective blocking effect on long-term potentiation (LTP) (20 mM), and also inhibits tetanus-induced short-term potentiation (STP) (200 mM) [1].
In Vivo:MCPG (Intracerebroventricular injection) can eliminate the enhancement of field excitatory postsynaptic potential (fEPSP) in the alveolar gyrus induced by tedium stimulation in male Wistar rats [1].
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