CHPG (sodium salt)
CAS No. : 1303993-73-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $175 | In-stock |
| 50mg | $315 | In-stock |
| 100mg | $560 | In-stock |
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| Cat. No. : | HY-101364A |
| M.Wt: | 223.59 |
| Formula: | C8H7ClNNaO3 |
| Purity: | >98 % |
| Solubility: | H2O : 6.67 mg/mL (ultrasonic;warming;heat to 80°C);DMSO : 100 mg/mL (ultrasonic) |
CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].
IC50 & Target: mGluR5, TSG-6/NF-κB[1], ERK, Akt[2]
In Vitro: CHPG sodium salt (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1].
CHPG sodium salt (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis[1].
CHPG sodium salt (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1].
In Vivo: CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume[2].
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