DL-AP5 (sodium)
CAS No. : 1303993-72-7
(Synonyms: 2-APV (sodium); DL-2-Amino-5-phosphonovaleric acid (sodium))
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| 5mg | $150 | In-stock |
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| Cat. No. : | HY-100714C |
| M.Wt: | 219.11 |
| Formula: | C5H11NNaO5P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina[1][2][3].
In Vitro: DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels[5].
DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation[5].
In Vivo: DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin[4].
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