KHK-IN-1
CAS No. : 1303469-70-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $240 | In-stock |
| 10mg | $370 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-12841 |
| M.Wt: | 422.55 |
| Formula: | C21H26N8S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 has potential for the study of diabetes and obesity[1].
IC50 & Target:IC50=12 nM (KHK)[1].
In Vitro:KHK-IN-1 stable in human and rat liver microsome preparations (88 and 72% remaining at 10 min) and do not significantly inhibit cytochrome P450s from human liver microsomes (1A2, 2C19, 2D6, 2C9, and 3A4)[1].
KHK-IN-1 (0-10 µM; incubate 30 min, then add to 15 mM fructose and incubate for another 3 h) inhibits production of F1P in HepG2 cell lysates with an IC50 value of 400 nM[1].
In Vivo:KHK-IN-1 (10 mg/kg; p.o.; single) shows oral bioavailability of 34% in rats[1].
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