Icatibant
CAS No. : 130308-48-4
(Synonyms: HOE 140)
| Size | Price | Stock |
|---|---|---|
| 1mg | $270 | In-stock |
| 5mg | $540 | In-stock |
| 10mg | $780 | In-stock |
| 25mg | $1404 | In-stock |
| 50mg | $2106 | In-stock |
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| Cat. No. : | HY-17446 |
| M.Wt: | 1304.52 |
| Formula: | C59H89N19O13S |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively[1][2][3]. In Vitro: Icatibant (10-30 μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors)[3]. In Vivo: Icatibant (0.3, or 1.5 mg/kg, subcutaneous administration twice daily in mice) shows a significant preventive effect on ulcerative Colitis[2].
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