Duocarmycin SA
CAS No. : 130288-24-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $840 | In-stock |
| 5mg | $1800 | In-stock |
| 10mg | $2800 | In-stock |
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| Cat. No. : | HY-12456 |
| M.Wt: | 477.47 |
| Formula: | C25H23N3O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2].
In Vitro:Duocarmycin SA (DSA) (0.1-1 nM; 72 hours) inhibits U-138 cell viability in a dose-dependent manner and activates apoptotic and necrotic pathways[2].
Duocarmycin SA (0.1 nM; 72 hours) sensitizes human glioma cells to proton irradiation[2].
In Vivo:Duocarmycin SA (0.143 mg/kg, i.p., single dose) shows antitumor activity in murine lymphocytic leukemia P388 transplanted in CDF1 mice and shows a significant 30% increase in life span[3].
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