GSK-114
CAS No. : 1301761-96-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $155 | In-stock |
| 25mg | $315 | In-stock |
| 50mg | $500 | In-stock |
| 100mg | $800 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117658 |
| M.Wt: | 417.48 |
| Formula: | C19H23N5O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 5.95 mg/mL (ultrasonic;warming;heat to 60°C) |
GSK-114 is a highly selective, orally active TNNI3K inhibitor (IC50= 25 nM). GSK-114 shows a 40-fold selectivity for TNNI3K over B-Raf kinase (IC50= 1 µM). Cardiac troponin I-interacting kinase (TNNI3K or CARK) is a member of the tyrosine-like kinase family that is selectively expressed in heart tissue[1]. In Vitro: At a concentration of 1 µM, GSK114 demonstrated an affinity for seven other kinases: ACK1, B-Raf, GAK, MEK5, PDGFRB, STK36, and ZAK[2]. In Vivo: GSK-114 affords the best balance of specificity and pharmacokinetics, demonstrating useful oral exposure (poDNAUC=0.18, Cmax=130 ng/ml @ 2 mg/kg, t1/2=3.6 hr, rat Fu=20.2%)[1].
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