E1R
CAS No. : 1301211-78-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $480 | In-stock |
| 25mg | $950 | In-stock |
| 50mg | $1450 | In-stock |
| 100mg | $2150 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-116463 |
| M.Wt: | 232.28 |
| Formula: | C13H16N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 60 mg/mL (ultrasonic) |
E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity[1]. In Vitro: The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10?μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([3H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells[1]. In Vivo: E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10?mg/kg; administered i.p. 60?min before the training session) significantly improves cognitive function in a dose-related manner in mice[1].
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