Mafenide (Acetate)

Mafenide Acetate is a potent sulfonamide antimicrobial agent. Mafenide Acetate exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide Acetate also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus). Mafenide Acetate can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds^[1][2][3][4]. In Vitro:Mafenide Acetate (5%) maintains antimicrobial activity with a zone of inhibition >2 mm against Staphylococcus aureus and Pseudomonas aeruginosa in vitro^[1].
Mafenide Acetate (2.5%-7.5%; 1-24 h) exhibits dose-dependent antifungal activity against filamentous fungi (e.g., Lichtheimia spp., Aspergillus flavus)^[3].
In Vivo:Mafenide Acetate (2.5% solution; soaked in hydrofiber or gauze dressings, applied topically; group 3: changed every 2 days, group 4: changed twice a day; 14 days) improves skin graft survival on day 7 but causes significant cytotoxicity and graft loss by day 14 in a Pseudomonas aeruginosa-contaminated full-thickness skin graft (FTSG) model in male Wistar albino rats^[4].