Levocetirizine (dihydrochloride)


CAS No. : 130018-87-0

(Synonyms: (R)-Cetirizine (dihydrochloride))

130018-87-0
Price and Availability of CAS No. : 130018-87-0
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5mg $25 In-stock
10mg $35 In-stock
50mg $75 In-stock
100mg $105 In-stock
200mg $150 In-stock
500mg $240 In-stock
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Cat. No. : HY-W010841
M.Wt: 461.81
Formula: C21H27Cl3N2O3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic)
Introduction of 130018-87-0 :

Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1]. In Vivo: Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t , AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats[1].

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