Quinine


CAS No. : 130-95-0

130-95-0
Price and Availability of CAS No. : 130-95-0
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Cat. No. : HY-D0143
M.Wt: 324.42
Formula: C20H24N2O2
Purity: >98 %
Solubility: H2O : < 0.1 mg/mL;DMSO : ≥ 100 mg/mL
Introduction of 130-95-0 :

Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2]. IC50 & Target: IC50: Parasite[1], 169 μM (mSlo3)[2] In Vitro: Quinine (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line[1].
Quinine (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line[1].
In Vivo: Quinine (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice[2].
Quinine (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats[3].

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