Adenosine-2'-monophosphate
CAS No. : 130-49-4
(Synonyms: 2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate)
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| Cat. No. : | HY-124151 |
| M.Wt: | 347.22 |
| Formula: | C10H14N5O7P |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic;adjust pH to 7 with NaOH);DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 80°C) |
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].
In Vitro: Adenosine-2'-monophosphate (2'-AMP) (0-100 µM; daily for 4 days) inhibits proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors[1].
Adenosine-2'-monophosphate (30 μM; 24 hours) inhibits LPS induced (100 ng/ml) TNF-α and CXCL10 production in primary murine microglia[1].
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