Vitamin K5 (hydrochloride)

Vitamin K5 hydrochloride is a photosensitizer and a antimicrobial agent. Vitamin K5 hydrochloride is a specific PKM2 inhibitor with IC₅₀ values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 hydrochloride induces apoptosis of colon 26 cells. Vitamin K5 hydrochloride can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages^[1][2][3]. In Vitro:Vitamin K5 (0-1600 μM) hydrochloride increases the antibacterial effects of UVA irradiation to Escherichia coli, Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Klebsiella pneumoniae^[1].
Vitamin K5 (250-1000 μM) hydrochloride generates superoxide anion radical and hydroxyl radical with a fixed UVA dose of 2.9 J cm^-2[1].
Vitamin K5 (0-100 μM; 1 h) hydrochloride dose-dependently inhibits the cellular glucose consumption and lactate production^[2].
Vitamin K5 hydrochloride dose-dependently suppresses the proliferation of colon 26 cells^[3].
Vitamin K5 hydrochloride induces cell apoptosis and increases activity of caspase-3 in colon 26 cells^[3].