Dapoxetine (hydrochloride)

Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE)^[1]. IC50 & Target:Target: serotonin reuptake^[1] In Vitro:Dapoxetine hydrochloride binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine dopamine.
Dapoxetine hydrochloride inhibits the uptake of [³H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [³H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [³H]dopamine by the dopamine reuptake transporter with IC₅₀ values of 202 nM and 1720 nM, respectively.^[1]
In Vivo:Dapoxetine hydrochloride (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats^[2].