Phytic acid (potassium)

Phytic acid (myo-Inositol) potassium is an orally active compound. Phytic acid potassium can be derived from the seeds of legumes. Phytic acid potassium is a [PO4]³- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid potassium attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid potassium can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research^{[1][2][3][4][5][6][7][8][9][10]}. In Vitro:Phytic acid (0.05%-0.4% (wt/wt), 5 min) potassium and sodium chloride show marked synergistic bactericidal effects against nonadapted and acid-adapted Escherichia coli O157:H7 strains^[2].
Phytic acid (1-5 mM, 2-3 h) potassium decreases the integrity of Caco-2 cell monolayers by modulating the TJ proteins' localization and down-regulating the expression levels of TJ proteins, and does not cause cytotoxicity to Caco-2 cells^[3].
Phytic acid (48-72 h) potassium provides complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein in MC65 cells^[5].
Phytic acid (≥1 mM) potassium stimulates suicidal human erythrocyte death^[6].
In Vivo:Phytic acid (2%, diet, ad libitum for 21 d) potassium reduces growth performance of pigs partly through reduced capacity of the small intestine to absorb Na^[4].
Phytic acid (2%, drinking water, 6 months) potassium improves Alzheimer's pathology (AP180, beclin-1, LC3B, sirtuin 1) in Tg2576 mice^[5].
Phytic acid (20 mg/kg, i.p., pretreatment at 5 h before coronary artery occlusion) potassium suppresses ischemia-induced hydroxyl radical generation in rat myocardium^[7].
Phytic acid (100 mg/kg/d, gavage, five days a week, 8 weeks) potassium shows protective effects against CCl₄ (HY-Y0298)-induced liver fibrosis in mice^[8].
Phytic acid (4% of rodent chow, diet, 30 days) potassium reduces lipogenic enzyme activities in diabetic rats^[9].
Phytic acid (1-2 g/100 g, in water, 13 weeks) potassium shows anticarcinogenic effect in colon carcinoma rats, with 36% (1 g/100 g Phytic acid) and 42% (2 g/100 g Phytic acid) reduction in ACF, respectively^[10].