Vorozole
CAS No. : 129731-10-8
(Synonyms: (+)-Vorozole; R83842)
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| Cat. No. : | HY-19599 |
| M.Wt: | 324.77 |
| Formula: | C16H13ClN6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Vorozole is a potent and selective, orally active non-steroidal aromatase inhibitor[1][2]. Vorozole shows antitumor activity in vivo. Vorozole has the potential for the research of mammary cancer[3].
In Vitro:Vorozole inhibits aromatase activity with an IC50s of 1.4 nM in FSH-stimulated rat granulosa cells[4].
In Vivo:Vorozole (0.8-1.25 mg/kg; Gavage; daily for 77 dayss) shows antitumor effect and increase the release of serum insulin-like growth factor (IGF)-1 and serum testosterone levels[3].
Vorozole (p.o.; 5 days) dose-dependently reduced uterus weight and completely inhibited tumor aromatase in ovariectomized nude mice[4].
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