Minalrestat
CAS No. : 129688-50-2
(Synonyms: ARI-509; WAY-ARI 509)
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| 5mg | $1232 | Get quote |
| 10mg | $1755 | Get quote |
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| Cat. No. : | HY-106877 |
| M.Wt: | 449.20 |
| Formula: | C19H11BrF2N2O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Minalrestat (ARI-509) is a potent and orally active aldose reductase inhibitor. Minalrestat can be used in the research of diabetes[1].
In Vitro:Minalrestat (100 μM) decreased intracellular sorbitol without affecting intracellular glucose in primary cultured rat mesangial cells[3].
Minalrestat (100 μM, 48 h) causes accumulation of PKC-α and -β2 in primary cultured rat mesangial cells[3].
In Vivo:Minalrestat (Oral gavage, 10 mg/kg/day, for 30 days) corrects the decreased microvascular reactivity in diabetic rats[1].
Minalrestat (Oral gavage, 10 mg/kg) restores the reduced number of leukocytes adhered and migrated leukocytes in postcapillary venules in diabetic rats[2].
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