Bizelesin
CAS No. : 129655-21-6
(Synonyms: NSC 615291; U-77779)
| Size | Price | Stock |
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| 1mg | $660 | In-stock |
| 5mg | $1670 | In-stock |
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| Cat. No. : | HY-111397 |
| M.Wt: | 815.70 |
| Formula: | C43H36Cl2N8O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity[1].
In Vitro: Bizelesin (0-5 μM, 4 h) can cause DNA-specific damage by targeting the AT-rich DNA domain in human cancer cell CEM cells, thereby causing damage to cancer cells, and has potential cancer therapeutic potential[1].
Bizelesin (0-500 nM) causes a 50% inhibition of DNA synthesis at a concentration of 10 nM, compared to a 50% inhibition of RNA synthesis at a concentration of 160 nM, at concentrations as high as 200 nM no inhibition of protein synthesis is observed in BSC-1 cells[2].
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