PF-5006739
CAS No. : 1293395-67-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $510 | In-stock |
| 100mg | $890 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12443 |
| M.Wt: | 419.45 |
| Formula: | C22H22FN7O |
| Purity: | >98 % |
| Solubility: |
PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2].
IC50 & Target:IC50: 3.9 nM (CK1δ) and 17.0 nM (CK1ε)[1]
In Vitro:PF-5006739 has low nM in vitro potency for CK1δ/ε (IC50 = 3.9 and 17 nM)[1].
PF-5006739 (0.4-50 μM, 5 d) causes a rapid and dose-dependent induction of mPER2::luc bioluminescence in WAT tissue explants[2].
In Vivo:PF-5006739 (10mg/kg/day, s.c., once daily) significantly improves blood glucose profiles in DIO mice[2].
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- Cat. No.:
- HY-12443
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