Fabesetron
CAS No. : 129300-27-2
(Synonyms: FK1052 (free base))
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| Cat. No. : | HY-105201 |
| M.Wt: | 293.36 |
| Formula: | C18H19N3O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fabesetron (FK1052) is an orally active 5-HT3 receptor antagonist with 5-HT4 receptor antagonistic activity. Fabesetron (FK1052) can be used in the study for both acute and delayed emesis induced by cancer chemotherapy[1][2].
In Vivo:Fabesetron (FK1052) (0.1 mg/kg p.o.) inhibits completely the increases in the colonic transit[1].
FK1052 (100 μg/kg) completely prevents emesis induced by cisplatin (18 mg/kg, i.p.) in Suncus murinus[2].
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