K-80003
CAS No. : 1292821-90-9
(Synonyms: TX-803)
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $208 | In-stock |
| 50mg | $600 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-U00458 |
| M.Wt: | 336.40 |
| Formula: | C22H21FO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 30 mg/mL (ultrasonic) |
K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth. IC50 & Target:Akt[1] In Vitro: When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization. Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions[2]. In Vivo: K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity to RXRα but lacks COX inhibitory activity[1].
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