Isoangustone A
CAS No. : 129280-34-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $275 | In-stock |
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| 10 mg | Get quote | |
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| Cat. No. : | HY-N4006 |
| M.Wt: | 422.47 |
| Formula: | C25H26O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death[1][2][3].
IC50 & Target:Apoptosis, Autophagy[2]
In Vitro:Isoangustone A (10 and 20 μM; 48 and 72 h) suppresses proliferation and induces G1 phase cell cycle arrest in SK-MEL-28 cells[1].
Isoangustone A (10 and 20 μM; 48 h) decreases the abundance of G1 phase-related proteins mediated through the Akt/GSK3β and MKK4/MKK7/JNKs signaling pathways[1].
Isoangustone A suppresses PI3-K, MKK4, and MKK7 kinase activities by directly binding in an ATP-competitive manner[1].
Isoangustone A (20 μM; 0.5-4 h) induces autophagy in colorectal cancer cells by activating AMPK signaling[2].
Isoangustone A (1-20 μM; 0-100 min) inhibits mitochondrial respiration[2].
Isoangustone A (15 μM; 6 h) induces SW480 cells apoptosis[2].
Isoangustone A (1-20 μΜ; 3 days) suppresses mesangial fibrosis and inflammation in human renal mesangial cells[3].
In Vivo:Isoangustone A (2 or 10 mg/kg; i.p.; daily for 35 days) significantly decreases tumor growth, volume, and weight of SK-MEL-28 xenografts in mice[1].
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