SPR inhibitor 3
CAS No. : 1292285-54-1
(Synonyms: SPRi3)
| Size | Price | Stock |
|---|---|---|
| 5mg | $143 | In-stock |
| 10mg | $204 | In-stock |
| 50mg | $693 | In-stock |
| 100mg | $748 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-115510 |
| M.Wt: | 262.30 |
| Formula: | C14H18N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels[1][2][3]. IC50 & Target: IC50: 74 nM (sepiapterin reductase)[1] In Vitro: SPR inhibitor 3 (SPRi3) also significantly reduces SPR activity in mouse primary cultures of sensory neurons (IC50=0.45 μM) without affecting the activity of GTP cyclohydroxylase 1 enzyme (GCH1)[1].
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