BI 99179
CAS No. : 1291779-76-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $295 | In-stock |
| 50mg | $500 | In-stock |
| 100mg | $850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16100 |
| M.Wt: | 391.46 |
| Formula: | C23H25N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C) |
BI 99179, a chemical probe, is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats[1][2].
IC50 & Target:IC50: 79 nM (FASN)[1]
In Vitro:BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM[1].
BI 99179 (BI-99179; 1, 2, and 4 μM) shows antiproliferative efficacy in human glioma GAMG cells[2].
In Vivo:BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg) with half life (t1/2) of 3.0 h[1].
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