Way 100252
CAS No. : 129041-16-3
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| Cat. No. : | HY-116484 |
| M.Wt: | 383.48 |
| Formula: | C26H25NO2 |
| Purity: | >98 % |
| Solubility: |
Way 100252 is a presynaptic GABA autoreceptor agonist. Way 100252 exerts its effect by inhibiting GABA release, and it suppresses GABA release induced by K+, Ca2+, Ouabain (HY-B1457) and electrical stimulation, with a more potent inhibitory effect on electrically evoked release. Way 100252 is used for studies related to GABAergic neurotransmission[1]. In Vitro:Way 100252 dose-dependently inhibits the release of [3H] GABA evoked by various stimuli in cross-cut rat cerebral cortical slices, with pD2 values of 5.8 (Ca2+), 7.4 (K+), 6.3 (electrical stimulation) and 6.0 (Ouabain (HY-B1457)) for different stimuli, respectively, and the maximum inhibitory effect ranges from 40% to 90%[1].
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