Buclizine (dihydrochloride)
CAS No. : 129-74-8
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| Cat. No. : | HY-A0128A |
| M.Wt: | 505.95 |
| Formula: | C28H35Cl3N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 2.5 mg/mL (ultrasonic) |
Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat and shows anti-tumor activity[1][2][3].
In Vitro: Buclizine (0.1-100 μM; 72 h) inhibits growth of MCF-7 cells[2].
Buclizine (9.625-77 μM; 72 h) arrests the cell cycle in the G1 phase in a dose-dependent manner[2].
Buclizine (0-75 μM; 72 h) decreases TCTP (translationally controlled tumor protein) and cell cycle regulatory proteins expression in MCF-7 cells, increases pro-apoptotic MCL-1S expression[2].
In Vivo: Buclizine dihydrochloride (30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation) shows potent teratogens in the rat[3].
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