Oxyphenbutazone
CAS No. : 129-20-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $87 | In-stock |
| 10mg | $135 | In-stock |
| 25mg | $262 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $672 | In-stock |
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| Cat. No. : | HY-B1355A |
| M.Wt: | 324.37 |
| Formula: | C19H20N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Oxyphenbutazone is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis[1][2].
IC50 & Target:COX, Bacteria[1][2]
In Vitro: Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells[1].
Oxyphenbutazone (2.5-7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells[1].
Oxyphenbutazone exhibits reparative effects in the hepatocytes[1].
In Vivo: Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.)[1].
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