Merbromin
CAS No. : 129-16-8
(Synonyms: Mercury dibromofluorescein (disodium salt); ZP1)
| Size | Price | Stock |
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| 1g | $60 | In-stock |
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| Cat. No. : | HY-B0961 |
| M.Wt: | 752.67 |
| Formula: | C20H10Br2HgNa2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 6.67 mg/mL (ultrasonic) |
Merbromin is a mixed inhibitor of the 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2, with an IC50 of 2.7 μM. Merbromin effectively inhibits the replication of the Zika virus (ZIKV) and shows anti-ZIKV activity by inhibiting ZIKVpro. Merbromin can also be used as a topical disinfectant for cuts and scrapes, and it serves as a biological dye[1][2].
In Vitro:Merbromin (0-10 μM) affects both the KM and Kcat of 3CLpro, where the KM value increases from 9.02 μM to 14.28 μM, and the Kcat value decreases from 1.45 min to 0.63 min[1].
Merbromin with the KD for 3CLpro is 0.23 μM[1].
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