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Warfarin (sodium)


CAS No. : 129-06-6

(Synonyms: WARF-42 (sodium); Athrombine-K (sodium))

129-06-6
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Cat. No. : HY-B0687A
M.Wt: 330.31
Formula: C19H15NaO4
Purity: >98 %
Solubility: DMSO : 35 mg/mL;H2O : 23.33 mg/mL (ultrasonic)
Introduction of 129-06-6 :

Warfarin sodium (WARF-42 sodium; Athrombine-K sodium) is a potent anticoagulant agent and a vitamin K1 recycling antagonist to deplete active vitamin K1. Warfarin sodium decreases blood coagulation and prevents blood clot formation by inhibiting vitamin K epoxide reductase[1][2]. IC50 & Target:IC50: vitamin K1 recycling[1] In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Warfarin can be used to induce arterial calcification[3].

Inducing arterial calcification[3]
Background
Warfarin promotes vascular calcification by affecting the synthesis of vitamin K-dependent proteins.
Specific Mmodeling Methods
Rat: 7-week-old • male Sprague-Dawley rats
Administration: 3 mg/g food • oral • treated for two weeks
Note
(1) Two weeks after Warfarin administration, EPA was administered to test the prevention of arterial calcification[3].
Modeling Indicators
Tissue changes: Intraarterial calcification, elastic fiber disorder and rupture, and macrophage infiltration were found in the abdominal aorta and common iliac arteries[3].
Molecular changes: Total cholesterol and triglyceride levels increased, OPN and ALP expressions decreased, and MCP-1 and MMP-9 expressions increased[3].
Opposite Product(s): Eicosapentaenoic Acid (HY-B0660)

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