I-BOP

I-BOP is an agonist for thromboxane A2 receptor (TP) with a K_D of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle^[1]. I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons^[2]. In Vitro:I-BOP (1-100 nM) activates the MAP kinase, stimulates the tyrosine phosphorylation, and thus causes the activation of PI3K signaling pathway^[1].
I-BOP (0.1-3 μM) enhances the synaptic transmission in hippocampal CA1 neuron at low concentration by increasing the neurotransmitter release, inhibits the excitatory synaptic transmission in hippocampal CA1 neuron through reduction of membrane input resistance at high concentration^[2].