VU0529331
CAS No. : 1286725-49-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $240 | In-stock |
| 10mg | $384 | In-stock |
| 25mg | $808 | In-stock |
| 50mg | $1253 | In-stock |
| 100mg | $1880 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-112705 |
| M.Wt: | 384.43 |
| Formula: | C22H20N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming) |
VU0529331 is a homomeric GIRK channel activator, with an EC50 value of 5.1 μM for human GIRK2 and an EC50 value of 22.3 μM for GIRK4. VU0529331 serves as a starting point for the development of non-GIRK1/X channel probes and also acts as a tool for studying homomeric GIRK channels. VU0529331 is applicable to research related to addiction, primary aldosteronism and delayed-onset obesity[1][2].
IC50 & Target:EC50: 5.1 µM (GIRK2), 5.2 µM (GIRK1/2)[1]
In Vitro:VU0529331 (1.23-22.3 μM) activates GIRK2, GIRK1/2, GIRK1/4, GIRK4, Kir6.1/SUR2a, and Kir6.1/SUR2b channels expressed in HEK293 cells with potencies ranging from 1.23 μM to 22.3 μM, is inactive on other tested potassium channels and α1 GlyR, and acts independently of Gi/o protein signaling[1].
VU0529331 (80 μM; increasing concentrations) increases functional currents through GIRK2 and GIRK1/2 channels expressed in HEK293 cells while preserving their inherent inward rectification and K+ selectivity, with greater activity on GIRK2 channels[1].
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