BMS-813160
CAS No. : 1286279-29-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $720 | In-stock |
| 100mg | $1200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-109593 |
| M.Wt: | 484.64 |
| Formula: | C25H40N8O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming);Ethanol : 100 mg/mL (ultrasonic) |
BMS-813160 is a potent and selective CCR2/5 dual antagonist. BMS-813160 binds with CCR2 and CCR5 with IC50s of 6.2 and 3.6 nM, respectively. BMS-813160 can be used for the research of inflammation[1][2]. IC50 & Target:IC50: 6.2 nM (CCR2), 3.6 nM (CCR5)[2] In Vitro:BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively[2]. BMS-813160 shows activities to CCR2 CTX, CCR2 CD11b, CCR5 CTX and CCR5 CD11b with IC50s of 0.8, 4.8, 1.1 and 5.7 nM, respectively[2]. In Vivo:BMS-813160 (10-160 mg/kg; p.o. twice a day for two days) inhibits the migration of inflammatory monocytes and macrophages in mouse thioglycollate-induced peritonitis model, and shows excellent oral bioavailability[2].
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