Romidepsin
CAS No. : 128517-07-7
(Synonyms: FK 228; FR 901228; NSC 630176)
| Size | Price | Stock |
|---|---|---|
| 1mg | $132 | In-stock |
| 5mg | $300 | In-stock |
| 10mg | $480 | In-stock |
| 25mg | $768 | In-stock |
| 50mg | $1120 | In-stock |
| 100mg | $1620 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15149 |
| M.Wt: | 540.70 |
| Formula: | C24H36N4O6S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively[1]. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis[2]. IC50 & Target: IC50: 36 nM (HDAC1), 47 nM (HDAC2) [1] In Vitro: Romidepsin (0-72 hours; 0-80 nM) inhibits proliferation of HCC cells in dose-dependent manner[2]. Romidepsin (0-48 hours; 0-60 nM) leads to a time- and dose-dependent induction of cell cycle arrest in the G2/M phase in HCC cells[2]. Romidepsin (0-48 hours; 0-60 nM) promotesapoptosis in HCC cells, increases c-caspase-3, c-caspase-9, and c-PARP protein expression[2]. In Vivo: Romidepsin (intraperitoneal injection; 0.5 and 1 mg/kg; every 3 day; 21 days) inhibited the tumor growth, reveals a higher expression of p-cdc25C, ki67, c-caspase-3 and c-PARP, and a lower expression of Ki-67 in Romidepsin treated tumors [2].
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