Arbutamine

Arbutamine is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine stimulates cardiac β₁-, tracheal β₂-, and adiopocyte β₃- adrenergic receptors. Arbutamine provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine can be used for cardiac stress agent ^[1][2][3]. IC50 & Target: β-adrenoceptor^[1] In Vitro: Arbutamine (0.1-100 nM) increases heart contractile force and pD₂ value of 8.45. Arbutamine has the affinity constants (KA) value of 7.32 for cardiac β₁-adrenergic receptors^[3]. In Vivo: Arbutamine (i.v.; 5, 10, 50, 100, and 250 ng/kg/min) increases mean heart rate, peak positive left ventricular pressure and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg)^[3].